Quorum Sensing and Phytochemicals

Antibiofilm activity and quorum sensing inhibitory potential of phytochemicals

Low concentrations of local honey modulate ETA expression, and quorum sensing related virulence in drug-resistant Pseudomonas aeruginosa recovered from infected burn wounds

Objective(s): Honey’s ability to kill microorganisms and even eradication of chronic infections with drug-resistant pathogens has been documented by numerous studies. The present study is focused on the action of honey in its sub-inhibitory levels to impact on the pathogens coordinated behaviors rather than killing them. Materials and Methods:</strong...

Mini Review of Phytochemicals and Plant Taxa with Activity as Microbial Biofilm and Quorum Sensing Inhibitors.

Microbial biofilms readily form on many surfaces in nature including plant surfaces. In order to coordinate the formation of these biofilms, microorganisms use a cell-to-cell communication system called quorum sensing (QS). As formation of biofilms on vascular plants may not be advantageous to the hosts, plants have developed inhibitors to interfere with these processes. In this mini review, re...

Analysis of Quorum Sensing Inhibition and Phytochemicals in Different Extracts of Garlic

Usage of Allium sativum L. bulb (Amaryllidaceae) against the pathogenesis of Pseudomonas aeruginosa is an emphasized approach. However, biological response and safety of herbal extracts depend upon the processing methods and solvents used in preparation. In this study, various garlic bulb extracts (ethanol, ethyl acetate, methanol, acetone, chloroform, toluene, raw and heated) were prepared and...

In silico structural analysis of quorum sensing genes in Vibrio fischeri

Quorum sensing controls the luminescence of Vibrio fischeri through the transcriptional activator LuxR and the specific autoinducer signal produced by luxI. Amino acid sequences of these two genes were analyzed using bioinformatics tools. LuxI consists of 193 amino acids and appears to contain five α-helices and six ß-sheets when analyzed by SSpro8. LuxI belongs to the autoinducer synthetase fa...